Friday, October 21, 2011

Legendary Entertainment names new board member (Reuters)

LOS ANGELES (TheWrap.com) ? A.G. Lafley, the former chairman, president and CEO of Procter & Gamble, has joined the board of directors of Legendary Entertainment, the company announced Thursday.

Lafley joins Legendary as the company expands significantly. It recently launched Legendary East, a joint venture in China. And while it has long been a co-producer, it is increasingly developing its own projects.

It also recently closed on a new $700 million credit facility and has a new television division and a new comics division.

During Lafley's years at Procter & Gamble, sales doubled, profits quadrupled and the company's market value increased by more than $100 billion, according to Legendary.

He's a graduate of Hamilton College and holds an MBA from the Harvard Business School.

He joins Jim Breyer, Larry Clark, Dick Cook, Joe Roth and chairman and CEO Thomas Tull.

Lafley adds heft to Legendary's already hefty board: Jim Breyer is a partner in Accel Partners and is CEO of Breyer Capital. He also serves on the boards of both Facebook and Wal Mart. Dick Cook is the former chairman of Walt Disney Studios, and Roth is a renowned producer.

Legendary's productions include Guillermo del Toro's upcoming "Pacific Rim," "Inception and "The Dark Knight."

Source: http://us.rd.yahoo.com/dailynews/rss/enindustry/*http%3A//news.yahoo.com/s/nm/20111020/media_nm/us_legendary

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Torrential rainstorm floods Rome (AP)

ROME ? A torrential rainstorm battered Rome during the morning rush hour Thursday, causing flash floods that killed one man, felled trees and blocked thousands of commuters from reaching their workplaces.

Firemen reported finding the body of a man who drowned in his basement apartment. Police rescued dozens of others from low-lying buildings.

Italian authorities said they received more than 5,000 calls for help during the storm. Trees were felled, subways were flooded and some roads crumbled.

Private schools in Rome urged parents to keep their children home for the day, saying classrooms were flooded and roads near schools impassable.

Hours after the rain stopped, cars remained trapped in massive traffic jams on the outskirts of the city.

Source: http://us.rd.yahoo.com/dailynews/rss/europe/*http%3A//news.yahoo.com/s/ap/20111020/ap_on_re_eu/eu_italy_weather

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Thursday, October 20, 2011

French credit review threatens euro zone rescues (Reuters)

PARIS (Reuters) ? Doubt cast on France's triple-A credit rating by Moody's raised uncertainty over Europe's hopes of drawing a line under its sovereign debt crisis, five days before a crucial EU summit.

The U.S. ratings agency said late on Monday it may slap a negative outlook on France's Aaa rating in the next three months if slower growth and the costs for helping bail out banks and other euro zone members stretch its budget too much.

"The deterioration in debt metrics and the potential for further contingent liabilities to emerge are exerting pressure on the stable outlook of the government's Aaa debt rating," Moody's said in its annual report on France.

The warning, which sent the risk premium on French government bonds shooting up to a euro lifetime high, came as European Union leaders are preparing measures to protect the region's financial system from a potential Greek debt default.

That strategy includes new steps to reduce Greece's debt, strengthening the capital of banks with exposure to troubled euro zone sovereigns and leveraging the euro zone's rescue fund to prevent market contagion to bigger economies.

The October 23 summit is likely to agree to leverage the bailout fund by allowing it to underwrite a portion of newly issued euro zone debt, euro zone officials said.

With about 300 billion euros of its 440 billion-euro capacity still available, by guaranteeing the first 20-30 percent of any losses, the European Financial Stability Facility could stretch three to five times further.

"This idea is the main contender," one official said.

Economy Minister Francois Baroin insisted that France's AAA status was not at risk but acknowledged that the 1.75 percent growth forecast on which the government has based its 2012 budget was over-optimistic and would have to be revised down.

"The triple-A is not in danger because we will be even ahead of schedule on passing deficit reduction measures," Baroin said on France 2 television.

"We will do everything to avoid being downgraded."

Asked if next year's outlook would have to be reduced in light of weak growth prospects, he added: "We will adapt it, that much is clear."

France and Germany, the two strongest economies among the 17 euro zone members, form the backbone of the EFSF rescue fund and are drafting a crisis-fighting strategy for Sunday's summit.

Without France's triple-A rating, the whole edifice of rescue measures for troubled peripheral euro zone states would begin to crumble, putting more weight on Germany, where there is a strong public backlash against bailouts.

German leaders on Monday doused market hopes of a miracle cure at Sunday's Brussels summit, saying no one should expect a "definitive solution."

German Chancellor Angela Merkel told a closed-door meeting of her Christian Democrats she favored having a permanent presence of the so-called "troika" of international inspectors in Greece to supervise its public finances if there were doubts about fiscal management, party sources said.

She also expected agreement on proposals to send euro zone countries that repeatedly breached EU deficit rules to the European Court of Justice, the sources said.

FRENCH SPREAD HITS RECORD

Analysts said Moody's move was unusual, since it had not put France on ratings watch, but it was a signal to the government that it needed to adopt a more realistic growth assumption and adjust its budget measures accordingly.

Monday's review was only a preliminary step, but a negative outlook would be a sign that Moody's could downgrade its rating on France in the next couple of years. It placed the United States's Aaa rating on negative outlook in August.

The two other major ratings agencies, Standard & Poor's and Fitch, reaffirmed Paris' triple-A rating in August when French banks came under fierce market pressure over their exposure to the weakest euro zone sovereigns.

The spread on French 10-year bonds over benchmark German bonds jumped to a 19-year high of 114 basis points, the first time it had breached 1 percentage point in more than a decade. Safe-haven German Bunds rose on ebbing hopes of a quick solution to the debt crisis.

The ratings review was a potential embarrassment for conservative President Nicolas Sarkozy, who is expected to run for re-election next April and May and faces a strong challenge from Socialist candidate Francois Hollande, who won a primary election run-off on Sunday.

Prime Minister Francois Fillon made clear in a television interview that if growth fell short of official forecasts, Paris would take further austerity measures.

But Philipp Waechter, head of economic research at Natixis Asset Management, said: "We're entering an election year. Before May 6, 2012, it will be complicated to take strong measures. The government's ability to respond is reduced."

In Greece, ships were harbored and trains halted on Tuesday as angry workers built momentum for "the mother of all strikes" expected to bring the entire country to a halt in protest against a new package of tax hikes and wage cuts.

Unions representing around half of Greece's 4 million-strong workforce have called a 48 hour general strike for Wednesday and Thursday to protest against a sweeping package of austerity measures due to be passed in parliament this week.

Prime Minister George Papandreou told the cabinet late on Monday: "The nation is at a crucial moment and we have to be united. In this battle, we need everyone."

Hours earlier, a deputy from Papandreou's party quit his seat in protest against what he called "unjust" steps. The lawmaker will be replaced by another socialist, so Papandreou's four-seat majority in the 300-strong assembly is unchanged.

Meanwhile Portugal, which has also received an EU/IMF bailout, announced a draconian 2012 budget that risks a severe recession. The European Commission called it "courageous."

Greece's overall debt is forecast to climb to 357 billion euros ($491.4 billion) this year, or 162 percent of annual economic output -- a level economists agree is unsustainable.

To reduce this mountain, euro zone leaders are racing to convince banks to accept "voluntary" writedowns of up to 50 percent on their sovereign holdings. At the same time, they are trying to agree on a blueprint for recapitalizing financial institutions at risk from the deepening crisis.

Negotiations with the Institute of International Finance, representing the banks, were continuing in Brussels after diplomats said Deutsche Bank chief Josef Ackermann, who is also chairman of the IIF, met EU Council President Herman Van Rompuy to discuss write-downs and recapitalization.

Ackermann has objected to efforts to force banks to raise more capital and IIF lead negotiator Charles Dallara told Reuters on Monday that bigger writedowns on Greek bonds could only happen if policymakers addressed broader sovereign debt issues in Europe.

(Additional reporting by Walter Brandimarte in New York, Geert de Clercq, Jean-Baptiste Vey and Matthieu Protard in Paris, Emelia Sithole-Matarise in London, John O'Donnell in Brussels, Edward Taylor in Frankfurt; Writing by Paul Taylor, editing by Mike Peacock)

Source: http://us.rd.yahoo.com/dailynews/rss/eurobiz/*http%3A//news.yahoo.com/s/nm/20111018/bs_nm/us_eurozone

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I Did a Crazy Fad Diet From the Internet

Those Internet ads that say you can ?lose a pound a day with one simple trick?? The hCG diet is one that you?ll find when you click on those. And there is a trick to succeeding on the diet: Don?t follow the plans on the Internet, which usually involve ordering homeopathic drops. The FDA considers the drops to be ?fraudulent and illegal,? though the agency rarely does anything about it. Instead, find a doctor to prescribe injections. They are considered off-label use for weight loss, but when I found out that my OB-GYN?the same woman who once changed her vacation plans to deliver one of my kids?was offering the diet through her practice, I figured it was safe enough to consider. I attended an information session, learned the pros and the cons, and thought about it. And then I mentally deducted all the money from my imaginary iPad fund (It cost me $450, which isn?t cheap, but then, neither is Nutrisystem), and went for it.

Source: http://feeds.slate.com/click.phdo?i=6b1216eb99b45148b65ec5786f31a4c9

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X-linked mental retardation protein is found to mediate synaptic plasticity in hippocampus

X-linked mental retardation protein is found to mediate synaptic plasticity in hippocampus

Wednesday, October 19, 2011

Scientists at Cold Spring Harbor Laboratory (CSHL) have solved part of a puzzle concerning the relationship between changes in the strength of synapses ? the tiny gaps across which nerve cells in the brain communicate ? and dysfunctions in neural circuits that have been linked with drug addiction, mental retardation and other cognitive disorders.

A team led by CSHL Professor Linda Van Aelst has pieced together essential steps in a signaling cascade within excitatory nerve cells that explains a key phenomenon called longterm depression, or LTD. The "depression" in question has nothing to do with the human illness with that name. Rather, it refers to a tamping-down of the strength of individual synapses ? what scientists call synaptic plasticity.

The mechanism behind LTD is called endocytosis. It involves a retraction of receptors where neurotransmitters can "dock." Van Aelst and colleagues have demonstrated how LTD works following activation of a class of receptors called group I metabotrobic glutamate receptors, or mGluRs.

It was known that longterm depression mediated by mGluRs depended in part on the rapid synthesis of specific proteins. Yet the identity of these proteins had largely remained a mystery. The CSHL scientists have now shown that locally rapid production of a protein called oligophrenin 1 (OPHN1) follows activation of group I mGluRs. OPHN1 in turn was shown to mediate LTD in hippocampal nerve cells, by interacting with yet another protein called EndophilinA2/3.

The result of this cascade of intracellular signals was dramatic: persistent removal of AMPA-type receptors at the excitatory synapse, and the onset of LTD. When rapid production of OPHN1 was blocked, mGluR-dependent LTD did not occur. These findings appear online today ahead of print in the journal Neuron.

Van Aelst explained the significance of the finding. "OPHN1 has two important functions that we know about. One is early in development, after synapses have appeared in the emerging nervous system. In this phase, OPHN1 in concert with other factors stabilizes receptors at synapses, and thus is essential in maintaining the structure of these essential features of neural circuitry.

"Our new findings show another vital role for OPHN1, later in development and into maturity. We assume that in response to behavioral stimuli ? we aren't yet sure what kind ? mGluRs are activated, setting off the series of steps that we identified: rapid upregulation of OPHN1, which binds to EndophilinA2/3, which in turn mediates the long-term removal of AMPA receptors."

OPHN1 is known to be associated with X-linked mental retardation and with other cognitive and behavioral deficits. The team hypothesizes that OPHN1-related changes in plasticity such as those described in their new work may be causally related to such pathology. They are investigating this possibility in their current work.

###

Cold Spring Harbor Laboratory: http://www.cshl.org

Thanks to Cold Spring Harbor Laboratory for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/114463/X_linked_mental_retardation_protein_is_found_to_mediate_synaptic_plasticity_in_hippocampus

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How Come All Captchas Don't Just Work Like This? [Video]

Is it just me or have Captchas gotten insanely freaking impossible these days? I mean, I can't even make out if I'm supposed to type in a letter, a number or a hieroglyphic. Annoying! We need a new Captcha method. What about drawing a shape? More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/MPy8hm62upQ/how-come-all-captchas-dont-just-work-like-this

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Wednesday, October 19, 2011

Preemies have a higher risk of autism: study (Reuters)

NEW YORK (Reuters Health) ? The risk of developing autism among children who were born prematurely is five times greater than among kids born after a full-term pregnancy, according to a new study.

"Although this group is not the first to report a higher prevalence of autism in the low birth weight infant population, they've done a better job than anyone else in confirming the diagnosis with gold standard tools," said Dr. Karl Kuban, chief of pediatric neurology at Boston Medical Center, who did not participate in the research.

The Centers for Disease Control and Prevention estimate that one out of every 100 eight-year-old kids has autism.

The new study, published in the journal Pediatrics, found that five out of every 100 young adults who was born weighing less than four and a half pounds had autism.

"Is it being born early that's leading to the problem, or is it that being born early and having autism share a common risk?" Kuban said. "We don't know."

The researchers followed several hundred premature babies from birth to 21 years of age.

Of the 189 young adults who went through an exam called the Autism Diagnostic Interview--Revised, 14 received an autism diagnosis.

"I was surprised," said Jennifer Pinto-Martin, a professor at the University of Pennsylvania who led the study.

Based on autism screens done during an earlier phase of this research, when the children were 16 years old, "I knew it would be higher than the general population...but I thought the rate would be about double," rather than five times as high, Pinto-Martin added.

The participants who had autism also had a high rate of other psychiatric disorders. Six of the 14 kids with autism had been diagnosed with another psychiatric disorder, such as phobias or attention-deficit hyperactivity disorder, at age 16.

Pinto-Martin and her colleagues did not show that being born early causes autism, but she said there is concern that prematurity puts babies' brains at a higher risk for injury, and perhaps that injury could have something to do with autism.

Her group is going back through ultrasound scans of the children's brains to look for possible signs of injury.

An earlier study in the UK and Ireland found that eight out of every 100 children born extremely prematurely -- before 26 weeks of pregnancy --developed autism (see Reuters Health story of February 11, 2011).

This rate is higher than what the current study found, probably because Pinto-Martin's group studied a broader range of preemies that included children born after 26 weeks of pregnancy.

She pointed out that when her research began in the 1980s, extremely premature babies were far less likely to survive than they are now.

"The profile of a low birth weight cohort today is going to look very different, and is likely to be filled with kids who have more risk," she told Reuters Health.

The vast majority of children born prematurely do not develop autism, and Pinto-Martin does not want her findings to alarm parents. "It's not something to worry about, but it's something to pay attention to."

SOURCE: http://bit.ly/n2zYhZ Pediatrics, online October 17, 2011.

Source: http://us.rd.yahoo.com/dailynews/rss/parenting/*http%3A//news.yahoo.com/s/nm/20111017/hl_nm/us_preemies

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